| Thursday, November 9, 2000 |
| |
| I. WELCOME AND INTRODUCTION |
| 8:15 - 8:30 |
|
| |
| II. GENDER DIFFERENCES IN GONADAL
FUNCTION |
| Chair - P. Hoyer
|
| 8:30 - 9:15 |
"Advances in Testicular Biology"
— Mike Griswold, Ph.D., Washington State University. |
| 9:15 - 10:00 |
"Advances in Ovarian Biology: Impact
of Genomic Revolution on Basic Research in Ovarian Physiology"
— Aaron Hsueh, Ph.D., Stanford University. |
| |
|
| 10:00 - 10:30 |
BREAK |
| |
|
|
III. MECHANISMS OF TESTICULAR TOXICITY
|
| Chair - R. Chapin |
|
|
| 10:30 - 11:10 |
"Finding the Testis Phthalate Target:
The Next Step" — Kim Boekelheide, MD, Ph.D.,
Brown University |
| 11:10 - 11:50 |
"Phthalate Esters: Anti-androgenic
Effects on Male Reproductive Development"—Paul
Foster, Ph.D., CIIT |
| 11:50 - 12:30 |
"Hepatic and Testicular Metabolism
of Xenobiotics" — Marion Miller, Ph.D., University
of California at Davis. |
| 12:30 - 12:50 |
DISCUSSION |
| |
|
| 12:50 - 2:00 |
LUNCH
|
| |
|
IV. MECHANISMS OF OVARIAN TOXICITY
|
|
Chair - S. Perreault
|
|
2:00 - 2:40
|
"Ovarian Responses to Phthalate Exposure"
— Barbara Davis, VDM, Ph.D., NIEHS. |
|
2:40 - 3:20
|
"Role of Hepatic Metabolism in VCH-Induced
Ovarian Toxicity" — I. Glenn Sipes, Ph.D.,
The University of Arizona.
|
| 3:20 - 4:00 |
BREAK |
| 4:00 - 4:40 |
"Molecular Mechanisms of VCH and its
Epoxide Metabolites in Causing Ovotoxicity" —
Patricia Hoyer, Ph.D., The University of Arizona.
|
| 4:40 - 5:00 |
DISCUSSION |
| |
|
|
5 - 7:30 P.M.
|
Trainee Poster Session and Reception |
| |
|
Friday, November 10, 2000
|
| |
| V. GENDER DIFFERENCES IN NEUROENDOCRINE
REGULATION |
| Chair - B. Davis |
| 8:30 - 9:15 |
"Advances in Neuroendocrine Research
— Neuroendocrine Regulation of the Reproductive Axis:
Common Pathways and Gender-specific Differences" —
Margaret Shupnik, Ph.D., University of Virginia.
|
| 9:15 - 9:55 |
"Atrazine Alters the Neuroendocrine
Control of Gonadal Function in Males and Females" —
Ralph Cooper, Ph.D., EPA. |
| 9:55 - 10:15 |
DISCUSSION |
| |
|
| 10:15 - 10:45 |
BREAK |
| |
| VI. GENDER DIFFERENCES IN REGULATION
OF SEXUAL DEVELOPMENT |
| Chair - S. Schrader |
| 10:45 - 11:30 |
"Growth Factor Regulation of Phenotypic
Sexual Differentiation in the Female and Male Fetus: Impact
of Endocrine Disruptors" — Mike Skinner, Ph.D.,
Washington State University. |
| 11:30 - 12:10 |
"Gender-specific Differences in the
Response of Maturing Gametes to Toxic Insult" —
Sally Perreault, Ph.D., EPA.
|
| 12:10 - 12:30 |
DISCUSSION |
| |
|
|
12:30 - 2:00
|
LUNCH |
| |
| VII. TRANSLATIONAL APPLICATIONS
IN REPRODUCTIVE TOXICOLOGY |
| Chair - I.G. Sipes |
| 2:00 - 2:40 |
"Dosing, Disposition, Metabolism: Fate
of Environmental Chemicals within a Living Organism"
— Melvin Andersen, Ph.D., Colorado State University. |
| 2:40 - 3:20 |
"Human Exposures to 2-bromopropane:
How this Information Led to Mechanistic Investigations in
Animals" — Steven Schrader, Ph.D., NIOSH. |
| 3:20 - 4:00 |
"Assessing Human Exposure to Phthalates:
Implications for Epidemiology Studies" — Jane
Hoppin, ScD, NIEHS.
|
| 4:00 - 4:20 |
DISCUSSION |
| |
|
| 5 - 7 P.M |
General Poster Session and Reception |
| |
| Saturday, November 11, 2000 |
| |
| VIII. IMPLEMENTING FUTURE STUDIES
IN REPRODUCTIVE TOXICOLOGY |
| Chair - J. Heindel |
| "New Technologies and Novel
Approaches" |
| 8:30 - 9:10 |
Laser Capture — Robert Chapin, Ph.D.,
NIEHS. |
| 9:10 - 9:50 |
Microarray — David Dix, Ph.D.,
EPA. |
| 9:50 - 10:30 |
Proteomics — Daniel C. Liebler,
Ph.D., SWEHSC. |
| 10:30 - 11:00 |
BREAK |
| 11:00 - 12:15 |
"Conclusions and Recommendations"
— Panel Discussion — Organizers and Audience. |
| 12:15 - 12:30 |
"Closing Remarks" |
